Cechnicki A, Cichocki Ł, Kalisz A, Błądziński P, Adamczyk P, Franczyk-Glita J. Psychiatry Res. Drancourt, N. and Dell'Osso, Bernardo Feature Flags last update: Tue Dec 08 2020 13:03:07 GMT+0000 (Coordinated Universal Time) Scott, J. Wydell, Taeko N. 2020 Aug 3;11:770. doi: 10.3389/fpsyt.2020.00770. 2013. 2014 Nov 30;219(3):420-5. doi: 10.1016/j.psychres.2014.05.046. Duration of untreated illness as a key to early intervention in schizophrenia: A review. Henry, C. This is usually defined as first anti-psychotic treatment but where not on medication can use engagement and treatment in an Early Intervention (EI) service. Altamura, A Carlo British Journal of Psychiatry 205:88–94, 2014 Crossref, Medline, Google Scholar Oldani, Lucio 2014 Dec;205(6):499. doi: 10.1192/bjp.205.6.499. Erritty, Philip Oliva, M. Demographic studies from various countries indicate that the duration of untreated psychosis ranges from 22 weeks to over 150 weeks, while the median is between 4 and 26 weeks [4–7]. Conclusions: Long DUP correlated statistically significantly with poor general symptomatic outcome, more severe positive and negative symptoms, lesser likelihood of remission and poor social functioning and global outcome (correlations 0.13-0.18). Mismatch Negativity Predicts Remission and Neurocognitive Function in Individuals at Ultra-High Risk for Psychosis. Background: Dobrea, Cristina Kessing, Lars Vedel 2016. View all Google Scholar citations Grancini, Benedetta Br J Psychiatry. Murru, A. NIH and Lambert, Martin Psychosis is one of the most debilitating psychiatric conditions with limited options to improve outcomes. Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. Bertsch, Jordan * Views captured on Cambridge Core between September 2016 - 8th December 2020. Mimura, Masaru Vieta, E. Presented at the 16th AEP Congress, Apr 5-9, 2008, Nice (F), Outcome measures in early psychosis; relevance of duration of untreated psychosis, Determinants of help-seeking and system related components of delay in the treatment of first-episode psychosis, Predictors of efficacy in depression prevention programmes. Oldani, Lucio 2012. doi: 10.1371/journal.pone.0240504. Palma, Cárol 2014. Encephale. During this period, it has been anecdotally noted that there is a long duration of untreated psychosis (DUP) in individuals with first episode psychosis. They searched a number of different databases using what seemed to be appropriate search terms. Kato, Noriko Lüdecke, D. 2016. Carpiniello, Bernardo Primavera, Diego "hasAccess": "0", Altamura, A. Carlo 2013. Farriols, Núria We identified 3493 unique publications, from which 33 samples met our predefined selection criteria. Bock, Camilla and Camuri, Giulia Benatti, Beatrice Baldwin, David S. Carpiniello, B. Grancini, Benedetta Grancini, Benedetta and Jörg, F. "comments": true, De Cagna, Francesca Nakagawa, Atsuo "relatedCommentaries": true, Duration of Untreated Psychosis (DUP) is commonly defined as the time interval between onset of definite positive psychotic symptoms and first appropriate treatment. Delays in referral of patients with social phobia, panic disorder and generalized anxiety disorder attending a specialist anxiety clinic. eCollection 2020. eCollection 2020. Sembira, Ester Zanouy, L. Associations between parental bonding during childhood and functional recovery in patients with schizophrenia. "languageSwitch": true The … Association between the duration of untreated psychosis and short- and long-term outcome in schizophrenia within the Northern Finland 1966 Birth Cohort. Ishii J, Kodaka F, Miyata H, Yamadera W, Seto H, Inamura K, Higuchi H, Tsuruoka Y, Shigeta M. PLoS One. Most data on duration of untreated psychosis (DUP) derives from high-income countries. Benatti, Beatrice "metrics": true, Schöttle, D. The duration of untreated illness (DUI), defined as the interval between the onset of a psychiatric disorder and the administration of the first pharmacological treatment, has been increasingly investigated in the last decade as a predictor of outcome across different psychiatric conditions including schizophrenia and psychotic disorders (duration of untreated psychosis), and mood and anxiety … and The interviews were analysed using a meaning condensation procedure. Duration of untreated psychosis has a significant effect on treatment adherence in the initial recovery phase. Dell'Osso, Bernardo Cremaschi, Laura 2014 Dec;205(6):499-500. doi: 10.1192/bjp.205.6.499a. Early intervention (EI) services for psychosis aim to reduce the duration of untreated psychosis (DUP) with intensive large‐scale multi‐focus initiatives, including public awareness campaigns. Baldwin, David S. Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review, Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis, How depressive symptoms correlate with stigma perception of mental illness, Impact of duration of untreated psychosis on pre-treatment, baseline, and outcome characteristics in an epidemiological first-episode psychosis cohort, The association between pre-morbid adjustment, duration of untreated psychosis and outcome in first-episode psychosis, Features associated with the delayed initiation of mood stabilizers at illness onset in bipolar disorder, The clinical characteristics of DSM-IV bipolar I and II disorders: baseline findings from the Jorvi Bipolar Study (JoBS), Diagnosis and treatment in the early illness phase of bipolar disorders, Duration of untreated illness in anxiety and mood disorders. The Texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorder, Adequacy of treatment received by diagnosed and undiagnosed patients with bipolar I and II disorders, Early age at onset of bipolar disorder is associated with more severe clinical features but delayed treatment seeking, Effectiveness and outcome predictors of long-term lithium prophylaxis in unipolar major depressive disorder, Prophylaxis latency and outcome in bipolar disorders, Altered dendritic spine density in animal models of depression and in response to antidepressant treatment, Depression: perspective from affective neuroscience, Hippocampal volume reduction in major depression, Hippocampal volume and depression. Introduction. }. 2013. Spagnolin, Gregorio Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP Query parameters: { Method: Jo M, Kim HJ, Rim SJ, Lee MG, Kim CE, Park S. PLoS One. and Kahn, J. P. Oldani, Lucio 1. 2011.  |  Frías, Álvaro Lajnef, M. Wajsbrot-Elgrabli, O. Converging evidence indicates that a prolonged DUI may be viewed as a negative prognostic factor in schizophrenia and increasing data point toward a similar conclusion in mood and anxiety disorders. 2020 Oct 15;15(10):e0240504. and Finally, given that DUI is supposed to be a potentially modifiable prognostic factor, intervention programs aimed to reduce this variable are briefly considered and discussed. 2020 May 20;23(1):434. doi: 10.4081/ripppo.2020.434. The duration of untreated psychosis, or DUP, is measured as the time from the beginning of psychotic symptoms to the time a person starts treatment for those symptoms or a diagnosed condition. Dobrea, Cristina Duration of Untreated Psychosis and Duration of Untreated, https://doi.org/10.1017/S1092852900000079. Introduction. Etain, B. Spagnolin, Gregorio Feature Flags: { 2013 Jan;143(1):3-10. doi: 10.1016/j.schres.2012.10.029. Part I: Treatment of bipolar depression, Texas Consensus Conference Panel on Medication Treatment of Bipolar Disorder. 2020 Sep 18;23(2):459. doi: 10.4081/ripppo.2020.459. and "crossMark": true, Natta, Werner Oldani, Lucio and Marcenaro, Maurizio Cattaneo, Alma First admissions for depression: is the ‘no-treatment interval’ a critical predictor of time to remission? Ruppelt, F. Duration of untreated illness in major depressive disorder: a naturalistic study, A short duration of untreated illness (DUI) improves response outcomes in first-depressive episodes, World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of bipolar disorders. Copyright © Cambridge University Press 2010, Hostname: page-component-b4dcdd7-xrv4g The British journal of psychiatry : the journal of mental science BACKGROUND Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. "metricsAbstractViews": false, Penttilä M, Jääskeläinen E, Hirvonen N, Isohanni M, Miettunen J. Br J Psychiatry. Fleischhacker, W. Wolfgang COVID-19 is an emerging, rapidly evolving situation. and eCollection 2020. Palazzo, Maria Carlotta Huerta-Ramírez, Raúl Glick, Ira D. 2008 Oct;42(12):982-90. doi: 10.1016/j.jpsychires.2007.12.001. Carrà, Giuseppe The aim of this study was to compare DUP in a high-income country with that in a LAMI country using the same methodology. Neurosci Lett. Camuri, Giulia Aims: Dell'Osso, Bernardo Schulte-Markwort, M. 2013. Altamura, Alfredo Carlo Dell’Osso, Bernardo Duration of untreated illness in panic disorder: a poor outcome risk factor? Raust, A. Meloni, M.L. Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear. This site needs JavaScript to work properly. Although the total duration of untreated illness may be more critical, the duration of untreated psychosis is a more realistic immediate target for strategies of early detection and intervention. Gard, S. Hypotheses on neurobiological mechanisms underpinning outcome differences in relation to a prolonged DUI are provided and methodological limitations related to the assessment of the DUI in published studies and clinical practice discussed. Gotelli, Simona Edwards et al. Objective: The duration of untreated psychosis (DUP) influences treatment outcome in schizophrenia but its relevance in untreated patients, ill for a very long duration, is not known. The authors conducted a systematic review and meta-analysis according to recognised (MOOSE) guidelines. Arici, Chiara } 1 One key strategy is reducing the duration of untreated psychosis (DUP), the time from the first symptom of psychosis to the start of treatment. Epub 2012 Nov 22. Context Duration of untreated psychosis (DUP) is the time from manifestation of the first psychotic symptom to initiation of adequate treatment. MBailara, K. Cañete, José Simma, Alexander M. Emergency department and early detection of adolescents and young adults at risk of developing mental disorders: an exploratory study. Epub 2014 Jun 2. Epub 2016 Oct 4. Clinical presentation and need for treatment of a cohort of subjects accessing to a mental illness prevention service. Numerous studies have suggested that patients with longer periods of untreated psychosis tend to fare worse than those who begin treatment earlier. Schoevers, R. A. 3 Penttilä M, Jääskeläinen E, Hirvonen N, et al. The long duration of untreated psychosis group (> 54 weeks) had greater deterioration in the premorbid phase, a weaker social network and were more withdrawn than the short duration of untreated psychosis group (< 54 weeks). 2015. Altamura, A. Carlo and Get access to the full version of this content by using one of the access options below. An inverse relationship between DUP and income and a longer DUP in low- and middle-income (LAMI) countries has been reported. Visser, E. Benatti, Beatrice Background: Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. A review of progressive brain changes in chronically ill patients with schizophrenia, Psychosis and brain volume changes during the first five years of schizophrenia, The relationship between duration of untreated psychosis and outcome: an eight-year prospective study, Lack of an inverse relationship between duration of untreated psychosis and cognitive function in first episode schizophrenia, Duration of untreated psychosis and neuropsychological function in first episode psychosis, Clinical epidemiologic first-episode psychosis: 1-year outcome and predictors, Duration of untreated psychosis and social function: 1-year follow-up study of first-episode schizophrenia, Duration of untreated psychosis as a predictor of outcome in first-episode schizophrenia: a retrospective study, Clinical variables related to suicide attempts in schizophrenic patients: a retrospective study, The glutamatergic dysfunction hypothesis for schizophrenia, Glutamate receptor dysfunction and schizophrenia, Factors affecting outcome in schizophrenia and their relevance for psychopharmacological treatment, Depression, negative symptoms, social stagnation and social decline in the early course of schizophrenia, Clinical and social determinants of duration of untreated psychosis in the AESOP first-episode psychosis study, Brain volume abnormalities in major depressive disorder: A meta-analysis of magnetic resonance imaging studies. and Vinberg, Maj The small but mostly consistent correlation between long DUP and poor outcome indicates that early intervention in psychosis may have at least subtle positive effects on the long-term course of illness. Álvarez, Ana Long DUP as a predictor of poor short-term outcome has been addressed in previous meta-analyses, but the long-term effects of DUP remain unclear. In a recent study 1 involving 404 patients with first-episode psychosis recruited at 34 community clinics in 21 different US states, we found that the median duration of untreated psychosis … and 2018 Mar 16;669:59-67. doi: 10.1016/j.neulet.2016.10.003. Altamura, A. Carlo Sado, Mitsuhiro Can we predict the persistence of depression? Please enable it to take advantage of the complete set of features! "peerReview": true, Zaytseva, Yuliya Duration of untreated psychosis (DUP) and the course of schizophrenia in a 20-year follow-up study. Dell'Osso, Bernardo Shmuckler, Alexander eCollection 2020 May 20. Vismara, Matteo In some studies of duration of untreated psychosis and clinical outcome, duration of untreated psychosis has been dichotomized at 1 week, 6 months, or 1 year (45–47). Camuri, Giulia Ayuso-Mateos, José Luis USA.gov. NLM "openAccess": "0", Dell’Osso, Bernardo Oldehinkel, A. J. "clr": false, Dell’Osso, Bernardo This data will be updated every 24 hours. Long duration of untreated psychosis has been associated with worse outcome in schizophrenia. 2013. 07 November 2014. Altamura, A. Carlo Dorodnova, Anna Duration of untreated psychosis (DUP) is a major contributor to the variation in outcomes following first episode psychosis [1, 2] and a robust predictor of poor outcomes [3, 4].Therefore, reducing DUP has become an international priority and much effort has been spent assessing the impact of early intervention services on DUP. Random effects weighted meta-analysis with correlation coefficients was used to pool the results. Sarikaya, G. Amore, Mario and To analyse the associations between DUP and long-term outcomes of schizophrenia. Through a Medline search, the present article highlights the role of the DUI in this group of psychiatric disorders, focusing on social and psychopathological determinants of the DUI, as well as the clinical consequences related to a longer DUI in terms of outcome. Long duration of untreated psychosis may limit the potential responsiveness of negative symptoms to treatment. Duration of untreated psychosis (DUP) is one of the few potentially modifiable predictors of outcomes of schizophrenia. eCollection 2020 Sep 7. Camuri, Giulia Arici, Chiara Raven, D. Takechi, Sayuri 2015. May duration of untreated illness influence the long-term course of major depressive disorder? 2013. Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views. Cremaschi, Laura : Duration of untreated psychosis as predictor of long-term outcome in schizophrenia: systematic review and meta-analysis. Total loading time: 0.43 and Are we reinforcing the anti-medical model? 2014. Movina, Larisa Cremaschi, Laura "lang": "en" and Results: The duration of untreated psychosis was on average very long (130 weeks), the median value was 54 weeks. "isLogged": "0", HHS In sub-Saharan Africa, DUP is up to five times longer than in high-income countries, with many patients going without antipsychotic medication for 5 years or longer. Longer duration of untreated psychosis (DUP) has been shown to be modestly but significantly associated with poor clinical and social outcomes (Marshall et al., 2005, Norman and Malla, 2001, Perkins et al., 2005).The exact mechanism of how DUP influences outcome remains unclear and there may be several confounds of this relationship (Morgan et al., 2006, Peralta … It has been postulated that a longer DUP leads to a poorer prognosis. This study divided a group of 34 first-episode patients with schizophrenia into two groups: those with a long and short duration of untreated psychosis. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 2016. Primavera, D. Palazzo, Carlotta 2015. Epub 2016 May 6. Schimmelmann BG, Huber CG, Lambert M, Cotton S, McGorry PD, Conus P. J Psychiatr Res.  |  Solmi M, Campeol M, Gentili F, Favaro A, Cremonese C. Res Psychother. Buoli, Massimiliano and The optimal duration of maintenance treatment, however, has not been determined, and patients at low risk for relapse following medication withdrawal cannot be identified with specificity. Buoli, Massimiliano Clipboard, Search History, and several other advanced features are temporarily unavailable. NCI CPTC Antibody Characterization Program. Cohen, R. F. A meta-analysis of MRI studies, Reduced volume of orbitofrontal cortex in major depression, Glial reduction in amygdale is due to oligodendrocytes, Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder, Subgenual prefrontal cortex abnormalities in mood disorders, Glial reduction in the subgenual prefrontal cortex in mood disorders, Adult brain neurogenesis and psychiatry: a novel theory of depression, Impairments of neuroplasticity and cellular resilience in severe mood disorders: implications for the development of novel therapeutics, Neural plasticity to stress and antidepressant treatment, Regulation of adult neurogenesis by antidepressant treatment, Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus, Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment, Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex, Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression, Untreated depression and hippocampal volume loss, Systematic review and meta-analysis of multiple-session early interventions following traumatic events, Multiple session early psychological interventions for the prevention of post-traumatic stress disorder. Bukh, Jens Drachmann Duration of untreated psychosis (DUP) is the time between onset of psychotic symptoms and initiation of antipsychotic medication. Oldani, Lucio Dobrea, Cristina Is the duration of untreated psychosis temporally stable? Altamura, Alfredo Carlo One way to transform the lives of young adults presenting with psychosis is to shorten the duration of untreated psychosis (DUP), explained John M. Kane, Professor of Psychiatry, Northwell Health, NY, in an inspiring plenary at IEPA 11. doi: 10.1371/journal.pone.0235736. When someone who has had a psychotic episode initially seeks treatment, however, he or she may have had a prolonged duration of untreated psychosis (DUP). However, the causes of this long delay remain poorly understood, and there is a need to search for the factors involved in such a delay in order to reduce the time of untreated psychosis. Camuri, Giulia A systematic literature search was performed using seven electronic databases and manual searches. 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